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Speech therapy designed to stimulate increased vocal fold adduction with instructions to “increase loudness”, the so called Lee Silverman Voice Treatment (LSVT), using various verbal cues to regulate speech volume, and percutaneous collagen augmentation of the vocal folds () have been used successfully to treat the hypophonic, hypokinetic dysarthria associated with PD.

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In addition, pramipexole in the treatment of the symptoms of RLS has been shown to be very effective.

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During the premarketing development of pramipexole, patients with either early or advanced Parkinson's disease were enrolled in clinical trials.

In a 1-year, blinded evaluation of efficacy and augmentation, we compared a dopaminergic drug (pramipexole), administered at doses approved by the Food and Drug Administration for the treatment of RLS, with a nondopaminergic drug (pregabalin), an α2δ ligand with analgesic and anticonvulsant activity that is currently approved for the treatment of pain and epilepsy.

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