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Phase III: The goal of the third stage of human testing is to determine whether the experimental agent is effective in a still larger population, typically several hundred to several thousand.
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Concerns have been raised regarding the possible immunosuppressive effect of splenectomy in patients with HIV infection.
As expected, hENT1 overexpression stimulated gemcitabine-induced cell death in PK1- and KLM1-GR ( and ), and hENT1 knockdown suppressed the co-treatment of gemcitabine- and zidovudine-induced hENT1 expression and cell death in PK1-GR (), suggesting that the upregulation of hENT1 expression is one of the mechanisms used by zidovudine for inducing resensitization to gemcitabine.
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