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The first 6 months I had a lot of bone pain and jerking reactions. Both have subsided. I do occasionally have those reactions, but very seldom. I was told just recently I am in remission, it took 2 1/2 years. The biggest down side is the cost. I did not get upset learning about my leukemia, but cried when I found out about the cost. I get help with my insurance and I am so thankful for PSI giving me some help with it as well.
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Targeted drugs are designed to attack cancer by focusing on a specific aspect of cancer cells that allows them to grow and multiply.

The occurrence of cytopenias in CML patients was also dependent on the stage of the disease.

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Sawyers et al found that among patients in myeloid blast crisis (260 patients) treatment with imatinib resulted in sustained hematologic responses lasting at least 4 weeks in 31% of patients, including complete hematologic responses in 8%.

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Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E.

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Detection of BCR-ABL gene mutations in Philadelphia chromosome positive leukemia patients resistant to STI-571 cancer therapy.

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Importantly, P-loop mutations together with the Thr315Ile mutation are more frequently found in patients with advanced disease and seem to be closely associated with progression of patients from chronic phase to accelerated phase or blast crisis ().

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The drug has since been approved to treat other types of leukemia and blood cancers, some rare skin cancers and some gastrointestinal tumors.


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With today's decision, and in only five years, Gleevec has now been approved in the US for seven diseases, including two solid tumors and five blood disorders with molecular targets known to be inhibited by the drug.

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The authors reported that 38 patients (26%) received the drug throughout their pregnancy (including women who terminated pregnancy or had spontaneous abortion).

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If the tumor starts to grow again, it may respond to increasing the dose of imatinib.

This means one of three things: Gleevec is working, and is keeping the GIST at bay or, Gleevec did its work and killed any remaining GIST cells, leaving me cancer free, or I could be one of the 5% to 10% who, after resection, would not get a recurrence anyway (low odds, but possible).

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Intensified consolidation therapy with dose-escalated doxorubicin did not improve the prognosis of adults with acute lymphoblastic leukemia: the JALSG-ALL97 study.

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Cases of tumor lysis syndrome (TLS), which refers to an electrolyte disturbance caused by the breakdown of tumor cells, have been reported and can be life threatening in some instances.

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