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Targeted drugs are designed to attack cancer by focusing on a specific aspect of cancer cells that allows them to grow and multiply.

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Sawyers et al found that among patients in myeloid blast crisis (260 patients) treatment with imatinib resulted in sustained hematologic responses lasting at least 4 weeks in 31% of patients, including complete hematologic responses in 8%.

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Importantly, P-loop mutations together with the Thr315Ile mutation are more frequently found in patients with advanced disease and seem to be closely associated with progression of patients from chronic phase to accelerated phase or blast crisis ().

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This means one of three things: Gleevec is working, and is keeping the GIST at bay or, Gleevec did its work and killed any remaining GIST cells, leaving me cancer free, or I could be one of the 5% to 10% who, after resection, would not get a recurrence anyway (low odds, but possible).

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Cases of tumor lysis syndrome (TLS), which refers to an electrolyte disturbance caused by the breakdown of tumor cells, have been reported and can be life threatening in some instances.

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