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I have been taking methotrexate for about 2 years for moderate rheumatoid arthritis (22.5mg weekly) and it does control inflammation. I recently stopped taking it for 3 months because I really don't like taking drugs and symptoms returned (inflammation in ankles, hip pain, stiffness) so I started taking it again and have no pain so obviously it was working.

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Methotrexate works wonders for my psoriasis. I have been suffering from Psoriasis covering my hands since I remember myself. It is very painful and looks disgusting especially in exacerbation. My palms crack and bleed and people are afraid of communicating with me. In my life I have tried many topicals and other meds but only Methotrexate made me give a sigh of relief. I'm happy to have found it!

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Liver histology in rheumatoid arthritis patients receiving long-term methotrexate therapy: a prospective study with baseline and sequential biopsy samples.

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Methotrexate administered weekly in low doses is a mainstay in the therapy of rheumatoid arthritis.

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