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How long does Pristiq side effects last? Pristiq has a relatively short half-life, at 11 hours. This means the medication will stay in the body for 11 hours. The longer the half-life, the less severe the withdrawal symptoms will be. Other drugs can have a half-life of up to 2-3 days, so the body has more time to adjust to not having the drug in its system.
Is Pristiq approved for anxiety? Pristiq is used off label for generalized anxiety disorder to some success, although a few studies have shown mixed results. Even though Pristiq is off label, two other SNRIs (Cymbalta and Effexor XR) have been approved for anxiety use, so there is reason to believe that Pristiq may be approved for the same purpose.
How long does it take to adjust to Effexor? Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
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